Publications from PubMed: 264

Rogov VV, Stolz A, Ravichandran AC, Rios-Szwed DO, Suzuki H, Kniss A, Löhr F, Wakatsuki S, Dötsch V, Dikic I, Dobson RC, McEwan DG. Structural and functional analysis of the GABARAP interaction motif (GIM). EMBO Rep. 2018. 19 (12): . Link

Nguyen TD, Shaid S, Vakhrusheva O, Koschade SE, Klann K, Thöken M, Baker F, Zhang J, Oellerich T, Sürün D, Derlet A, Haberbosch I, Eimer S, Osiewacz HD, Behrends C, Münch C, Dikic I, Brandts CH. Loss of the selective autophagy receptor p62 impairs murine myeloid leukemia progression and mitophagy. Blood 2018.  (): . Link

Dikic I. Open questions: why should we care about ER-phagy and ER remodelling? BMC Biol. 2018. 16 (1): 131. Link

Herhaus L, Dikic I. Dimerization quality control via ubiquitylation. Science 2018. 362 (6411): 151-152. Link

Stolz A, Dikic I. Elusive mitochondrial connection to inflammation uncovered. Nature 2018. 561 (7722): 185-186. Link

Grumati P, Dikic I, Stolz A. ER-phagy at a glance. J. Cell. Sci. 2018. 131 (17): . Link

Kalayil S, Bhogaraju S, Bonn F, Shin D, Liu Y, Gan N, Basquin J, Grumati P, Luo ZQ, Dikic I. Insights into catalysis and function of phosphoribosyl-linked serine ubiquitination. Nature 2018. 557 (7707): 734-738. Link

Münch C, Dikic I. Publisher Correction: Hitchhiking on selective autophagy. Nat. Cell Biol. 2018. 20 (8): 990. Link

Dikic I, Elazar Z. Mechanism and medical implications of mammalian autophagy. Nat. Rev. Mol. Cell Biol. 2018. 19 (6): 349-364. Link

Herhaus L, Dikic I. Ubiquitin-induced phase separation of p62/SQSTM1. Cell Res. 2018. 28 (4): 389-390. Link

Das CK, Linder B, Bonn F, Rothweiler F, Dikic I, Michaelis M, Cinatl J, Mandal M, Kögel D. BAG3 Overexpression and Cytoprotective Autophagy Mediate Apoptosis Resistance in Chemoresistant Breast Cancer Cells. Neoplasia 2018. 20 (3): 263-279. Link

Münch C, Dikic I. Hitchhiking on selective autophagy. Nat. Cell Biol. 2018. 20 (2): 122-124. Link

Kniss A, Schuetz D, Kazemi S, Pluska L, Spindler PE, Rogov VV, Husnjak K, Dikic I, Güntert P, Sommer T, Prisner TF, Dötsch V. Chain Assembly and Disassembly Processes Differently Affect the Conformational Space of Ubiquitin Chains. Structure 2018. 26 (2): 249-258.e4. Link

Ramadan K, Dikic I. Editorial: Ubiquitin and Ubiquitin-Relative SUMO in DNA Damage Response. Front Genet 2017. 8 (): 188. Link

Liu Q, Kistemaker HAV, Bhogaraju S, Dikic I, Overkleeft HS, van der Marel GA, Ovaa H, van der Heden van Noort GJ, Filippov DV. A General Approach Towards Triazole-Linked Adenosine Diphosphate Ribosylated Peptides and Proteins. Angew. Chem. Int. Ed. Engl. 2018. 57 (6): 1659-1662. Link

Stolz A, Dikic I. Heterotypic Ubiquitin Chains: Seeing is Believing. Trends Cell Biol. 2018. 28 (1): 1-3. Link

Grumati P, Dikic I. Ubiquitin signaling and autophagy. J. Biol. Chem. 2018. 293 (15): 5404-5413. Link

Sairenji TJ, Ikezawa J, Kaneko R, Masuda S, Uchida K, Takanashi Y, Masuda H, Sairenji T, Amano I, Takatsuru Y, Sayama K, Haglund K, Dikic I, Koibuchi N, Shimokawa N. Maternal prolactin during late pregnancy is important in generating nurturing behavior in the offspring. Proc. Natl. Acad. Sci. U.S.A. 2017. 114 (49): 13042-13047. Link

Herhaus L, Dikic I. Regulation of Salmonella-host cell interactions via the ubiquitin system. Int. J. Med. Microbiol. 2017.  (): . Link

Amstein L, Ackermann J, Scheidel J, Fulda S, Dikic I, Koch I. Manatee invariants reveal functional pathways in signaling networks. BMC Syst Biol 2017. 11 (1): 72. Link

Rogov VV, Stolz A, Ravichandran AC, Rios-Szwed DO, Suzuki H, Kniss A, Löhr F, Wakatsuki S, Dötsch V, Dikic I, Dobson RC, McEwan DG. Structural and functional analysis of the GABARAP interaction motif (GIM). EMBO Rep. 2017. 18 (8): 1382-1396. Link

Grumati P, Morozzi G, Hölper S, Mari M, Harwardt MI, Yan R, Müller S, Reggiori F, Heilemann M, Dikic I. Full length RTN3 regulates turnover of tubular endoplasmic reticulum via selective autophagy. Elife 2017. 6 (): . Link

Galluzzi L, Baehrecke EH, Ballabio A, Boya P, Bravo-San Pedro JM, Cecconi F, Choi AM, Chu CT, Codogno P, Colombo MI, Cuervo AM, Debnath J, Deretic V, Dikic I, Eskelinen EL, Fimia GM, Fulda S, Gewirtz DA, Green DR, Hansen M, Harper JW, Jäättelä M, Johansen T, Juhasz G, Kimmelman AC, Kraft C, Ktistakis NT, Kumar S, Levine B, Lopez-Otin C, Madeo F, Martens S, Martinez J, Melendez A, Mizushima N, Münz C, Murphy LO, Penninger JM, Piacentini M, Reggiori F, Rubinsztein DC, Ryan KM, Santambrogio L, .... Molecular definitions of autophagy and related processes. EMBO J. 2017. 36 (13): 1811-1836. Link

Sakamaki JI, Wilkinson S, Hahn M, Tasdemir N, O'Prey J, Clark W, Hedley A, Nixon C, Long JS, New M, Van Acker T, Tooze SA, Lowe SW, Dikic I, Ryan KM. Bromodomain Protein BRD4 Is a Transcriptional Repressor of Autophagy and Lysosomal Function. Mol. Cell 2017. 66 (4): 517-532.e9. Link

van Wijk SJL, Fricke F, Herhaus L, Gupta J, Hötte K, Pampaloni F, Grumati P, Kaulich M, Sou YS, Komatsu M, Greten FR, Fulda S, Heilemann M, Dikic I. Linear ubiquitination of cytosolic Salmonella Typhimurium activates NF-κB and restricts bacterial proliferation. Nat Microbiol 2017. 2 (): 17066. Link

Dikic I. Proteasomal and Autophagic Degradation Systems. Annu. Rev. Biochem. 2017. 86 (): 193-224. Link

Rogov VV, Suzuki H, Marinković M, Lang V, Kato R, Kawasaki M, Buljubašić M, Šprung M, Rogova N, Wakatsuki S, Hamacher-Brady A, Dötsch V, Dikic I, Brady NR, Novak I. Phosphorylation of the mitochondrial autophagy receptor Nix enhances its interaction with LC3 proteins. Sci Rep 2017. 7 (1): 1131. Link

Šprung M, Dikic I, Novak I. Flow Cytometer Monitoring of Bnip3- and Bnip3L/Nix-Dependent Mitophagy. Methods Mol. Biol. 2018. 1759 (): 105-110. Link

Peng H, Yang J, Li G, You Q, Han W, Li T, Gao D, Xie X, Lee BH, Du J, Hou J, Zhang T, Rao H, Huang Y, Li Q, Zeng R, Hui L, Wang H, Xia Q, Zhang X, He Y, Komatsu M, Dikic I, Finley D, Hu R. Ubiquitylation of p62/sequestosome1 activates its autophagy receptor function and controls selective autophagy upon ubiquitin stress. Cell Res. 2017. 27 (5): 657-674. Link

Jung J, Nayak A, Schaeffer V, Starzetz T, Kirsch AK, Müller S, Dikic I, Mittelbronn M, Behrends C. Multiplex image-based autophagy RNAi screening identifies SMCR8 as ULK1 kinase activity and gene expression regulator. Elife 2017. 6 (): . Link

Fiskin E, Bhogaraju S, Herhaus L, Kalayil S, Hahn M, Dikic I. Structural basis for the recognition and degradation of host TRIM proteins by Salmonella effector SopA. Nat Commun 2017. 8 (): 14004. Link

Diamanti MA, Gupta J, Bennecke M, De Oliveira T, Ramakrishnan M, Braczynski AK, Richter B, Beli P, Hu Y, Saleh M, Mittelbronn M, Dikic I, Greten FR. IKKα controls ATG16L1 degradation to prevent ER stress during inflammation. J. Exp. Med. 2017. 214 (2): 423-437. Link

Stolz A, Putyrski M, Kutle I, Huber J, Wang C, Major V, Sidhu SS, Youle RJ, Rogov VV, Dötsch V, Ernst A, Dikic I. Fluorescence-based ATG8 sensors monitor localization and function of LC3/GABARAP proteins. EMBO J. 2017. 36 (4): 549-564. Link

Bhogaraju S, Kalayil S, Liu Y, Bonn F, Colby T, Matic I, Dikic I. Phosphoribosylation of Ubiquitin Promotes Serine Ubiquitination and Impairs Conventional Ubiquitination. Cell 2016. 167 (6): 1636-1649.e13. Link

Tooze SA, Dikic I. Autophagy Captures the Nobel Prize. Cell 2016. 167 (6): 1433-1435. Link

Scheidel J, Amstein L, Ackermann J, Dikic I, Koch I. In Silico Knockout Studies of Xenophagic Capturing of Salmonella. PLoS Comput. Biol. 2016. 12 (12): e1005200. Link

Seczynska M, Dikic I. Removing the waste bags: how p97 drives autophagy of lysosomes. EMBO J. 2017. 36 (2): 129-131. Link

Lopez-Mosqueda J, Maddi K, Prgomet S, Kalayil S, Marinovic-Terzic I, Terzic J, Dikic I. SPRTN is a mammalian DNA-binding metalloprotease that resolves DNA-protein crosslinks. Elife 2016. 5 (): . Link

Hoeller D, Dikic I. How the proteasome is degraded. Proc. Natl. Acad. Sci. U.S.A. 2016. 113 (47): 13266-13268. Link

Teng B, Schroder P, Müller-Deile J, Schenk H, Staggs L, Tossidou I, Dikic I, Haller H, Schiffer M. CIN85 Deficiency Prevents Nephrin Endocytosis and Proteinuria in Diabetes. Diabetes 2016. 65 (12): 3667-3679. Link

Weishaupt JH, Hyman T, Dikic I. Common Molecular Pathways in Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Trends Mol Med 2016. 22 (9): 769-783. Link

Fiskin E, Bionda T, Dikic I, Behrends C. Global Analysis of Host and Bacterial Ubiquitinome in Response to Salmonella Typhimurium Infection. Mol. Cell 2016. 62 (6): 967-981. Link

Bhogaraju S, Dikic I. Cell biology: Ubiquitination without E1 and E2 enzymes. Nature 2016. 533 (7601): 43-4. Link

Suzuki N, Rohaim A, Kato R, Dikic I, Wakatsuki S, Kawasaki M. A novel mode of ubiquitin recognition by the ubiquitin-binding zinc finger domain of WRNIP1. FEBS J. 2016. 283 (11): 2004-17. Link

Richter B, Sliter DA, Herhaus L, Stolz A, Wang C, Beli P, Zaffagnini G, Wild P, Martens S, Wagner SA, Youle RJ, Dikic I. Phosphorylation of OPTN by TBK1 enhances its binding to Ub chains and promotes selective autophagy of damaged mitochondria. Proc. Natl. Acad. Sci. U.S.A. 2016. 113 (15): 4039-44. Link

Baccarini M, Dikic I. Editorial overview: Cell regulation. Curr. Opin. Cell Biol. 2016. 39 (): iv-vi. Link

Nastase MV, Zeng-Brouwers J, Frey H, Hsieh LT, Poluzzi C, Beckmann J, Schroeder N, Pfeilschifter J, Lopez-Mosqueda J, Mersmann J, Ikeda F, Iozzo RV, Dikic I, Schaefer L. An Essential Role for SHARPIN in the Regulation of Caspase 1 Activity in Sepsis. Am. J. Pathol. 2016. 186 (5): 1206-20. Link

Maculins T, Fiskin E, Bhogaraju S, Dikic I. Bacteria-host relationship: ubiquitin ligases as weapons of invasion. Cell Res. 2016. 26 (4): 499-510. Link

Jennewein L, Ronellenfitsch MW, Antonietti P, Ilina EI, Jung J, Stadel D, Flohr LM, Zinke J, von Renesse J, Drott U, Baumgarten P, Braczynski AK, Penski C, Burger MC, Theurillat JP, Steinbach JP, Plate KH, Dikic I, Fulda S, Brandts C, Kögel D, Behrends C, Harter PN, Mittelbronn M. Diagnostic and clinical relevance of the autophago-lysosomal network in human gliomas. Oncotarget 2016. 7 (15): 20016-32. Link

Habisov S, Huber J, Ichimura Y, Akutsu M, Rogova N, Loehr F, McEwan DG, Johansen T, Dikic I, Doetsch V, Komatsu M, Rogov VV, Kirkin V. Structural and Functional Analysis of a Novel Interaction Motif within UFM1-activating Enzyme 5 (UBA5) Required for Binding to Ubiquitin-like Proteins and Ufmylation. J. Biol. Chem. 2016. 291 (17): 9025-41. Link

Rajalingam K, Dikic I. SnapShot: Expanding the Ubiquitin Code. Cell 2016. 164 (5): 1074-1074.e1. Link

Akutsu M, Dikic I, Bremm A. Ubiquitin chain diversity at a glance. J. Cell. Sci. 2016. 129 (5): 875-80. Link

Klionsky DJ, Abdelmohsen K, Abe A, Abedin MJ, Abeliovich H, Acevedo Arozena A, Adachi H, Adams CM, Adams PD, Adeli K, Adhihetty PJ, Adler SG, Agam G, Agarwal R, Aghi MK, Agnello M, Agostinis P, Aguilar PV, Aguirre-Ghiso J, Airoldi EM, Ait-Si-Ali S, Akematsu T, Akporiaye ET, Al-Rubeai M, Albaiceta GM, Albanese C, Albani D, Albert ML, Aldudo J, Algül H, Alirezaei M, Alloza I, Almasan A, Almonte-Beceril M, Alnemri ES, Alonso C, Altan-Bonnet N, Altieri DC, Alvarez S, Alvarez-Erviti L, Alves S, Amad.... Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy 2016. 12 (1): 1-222. Link

Gomes LC, Odedra D, Dikic I, Pohl C. Autophagy and modular restructuring of metabolism control germline tumor differentiation and proliferation in C. elegans. Autophagy 2016. 12 (3): 529-46. Link

Kern A, Dikic I, Behl C. The integration of autophagy and cellular trafficking pathways via RAB GAPs. Autophagy 2015. 11 (12): 2393-7. Link

Khaminets A, Behl C, Dikic I. Ubiquitin-Dependent And Independent Signals In Selective Autophagy. Trends Cell Biol. 2016. 26 (1): 6-16. Link

Herhaus L, Dikic I. Expanding the ubiquitin code through post-translational modification. EMBO Rep. 2015. 16 (9): 1071-83. Link

Leznicki P, Korac-Prlic J, Kliza K, Husnjak K, Nyathi Y, Dikic I, High S. Binding of SGTA to Rpn13 selectively modulates protein quality control. J. Cell. Sci. 2015. 128 (17): 3187-96. Link

Khaminets A, Heinrich T, Mari M, Grumati P, Huebner AK, Akutsu M, Liebmann L, Stolz A, Nietzsche S, Koch N, Mauthe M, Katona I, Qualmann B, Weis J, Reggiori F, Kurth I, Hübner CA, Dikic I. Regulation of endoplasmic reticulum turnover by selective autophagy. Nature 2015. 522 (7556): 354-8. Link

McEwan DG, Dikic I. PLEKHM1: Adapting to life at the lysosome. Autophagy 2015. 11 (4): 720-2. Link

Freischmidt A, Wieland T, Richter B, Ruf W, Schaeffer V, Müller K, Marroquin N, Nordin F, Hübers A, Weydt P, Pinto S, Press R, Millecamps S, Molko N, Bernard E, Desnuelle C, Soriani MH, Dorst J, Graf E, Nordström U, Feiler MS, Putz S, Boeckers TM, Meyer T, Winkler AS, Winkelman J, de Carvalho M, Thal DR, Otto M, Brännström T, Volk AE, Kursula P, Danzer KM, Lichtner P, Dikic I, Meitinger T, Ludolph AC, Strom TM, Andersen PM, Weishaupt JH. Haploinsufficiency of TBK1 causes familial ALS and fronto-temporal dementia. Nat. Neurosci. 2015. 18 (5): 631-6. Link

McEwan DG, Dikic I. Cullins keep autophagy under control. Dev. Cell 2014. 31 (6): 675-6. Link

Stolz A, Dikic I. PINK1-PARKIN interplay: down to ubiquitin phosphorylation. Mol. Cell 2014. 56 (3): 341-2. Link

McEwan DG, Richter B, Claudi B, Wigge C, Wild P, Farhan H, McGourty K, Coxon FP, Franz-Wachtel M, Perdu B, Akutsu M, Habermann A, Kirchof A, Helfrich MH, Odgren PR, Van Hul W, Frangakis AS, Rajalingam K, Macek B, Holden DW, Bumann D, Dikic I. PLEKHM1 regulates Salmonella-containing vacuole biogenesis and infection. Cell Host Microbe 2015. 17 (1): 58-71. Link

McEwan DG, Popovic D, Gubas A, Terawaki S, Suzuki H, Stadel D, Coxon FP, Miranda de Stegmann D, Bhogaraju S, Maddi K, Kirchof A, Gatti E, Helfrich MH, Wakatsuki S, Behrends C, Pierre P, Dikic I. PLEKHM1 regulates autophagosome-lysosome fusion through HOPS complex and LC3/GABARAP proteins. Mol. Cell 2015. 57 (1): 39-54. Link

Spang N, Feldmann A, Huesmann H, Bekbulat F, Schmitt V, Hiebel C, Koziollek-Drechsler I, Clement AM, Moosmann B, Jung J, Behrends C, Dikic I, Kern A, Behl C. RAB3GAP1 and RAB3GAP2 modulate basal and rapamycin-induced autophagy. Autophagy 2014. 10 (12): 2297-309. Link

Kumari S, Redouane Y, Lopez-Mosqueda J, Shiraishi R, Romanowska M, Lutzmayer S, Kuiper J, Martinez C, Dikic I, Pasparakis M, Ikeda F. Sharpin prevents skin inflammation by inhibiting TNFR1-induced keratinocyte apoptosis. Elife 2014. 3 (): . Link

Popovic D, Vucic D, Dikic I. Ubiquitination in disease pathogenesis and treatment. Nat. Med. 2014. 20 (11): 1242-53. Link

Dikic I, Bremm A. DUBs counteract parkin for efficient mitophagy. EMBO J. 2014. 33 (21): 2442-3. Link

Lessel D, Vaz B, Halder S, Lockhart PJ, Marinovic-Terzic I, Lopez-Mosqueda J, Philipp M, Sim JC, Smith KR, Oehler J, Cabrera E, Freire R, Pope K, Nahid A, Norris F, Leventer RJ, Delatycki MB, Barbi G, von Ameln S, Högel J, Degoricija M, Fertig R, Burkhalter MD, Hofmann K, Thiele H, Altmüller J, Nürnberg G, Nürnberg P, Bahlo M, Martin GM, Aalfs CM, Oshima J, Terzic J, Amor DJ, Dikic I, Ramadan K, Kubisch C. Mutations in SPRTN cause early onset hepatocellular carcinoma, genomic instability and progeroid features. Nat. Genet. 2014. 46 (11): 1239-44. Link

Bhogaraju S, Dikic I. A peek into the atomic details of thalidomide's clinical effects. Nat. Struct. Mol. Biol. 2014. 21 (9): 739-40. Link

Stolz A, Ernst A, Dikic I. Cargo recognition and trafficking in selective autophagy. Nat. Cell Biol. 2014. 16 (6): 495-501. Link

López-Mosqueda J, Dikic I. Deciphering functions of branched ubiquitin chains. Cell 2014. 157 (4): 767-9. Link

Gomes LC, Dikic I. Autophagy in antimicrobial immunity. Mol. Cell 2014. 54 (2): 224-33. Link

Schaeffer V, Akutsu M, Olma MH, Gomes LC, Kawasaki M, Dikic I. Binding of OTULIN to the PUB domain of HOIP controls NF-κB signaling. Mol. Cell 2014. 54 (3): 349-61. Link

Grumati P, Dikic I. Germline polymorphisms in RNF31 regulate linear ubiquitination and oncogenic signaling. Cancer Discov 2014. 4 (4): 394-6. Link

Tufar P, Rahighi S, Kraas FI, Kirchner DK, Löhr F, Henrich E, Köpke J, Dikic I, Güntert P, Marahiel MA, Dötsch V. Crystal structure of a PCP/Sfp complex reveals the structural basis for carrier protein posttranslational modification. Chem. Biol. 2014. 21 (4): 552-562. Link

Popovic D, Dikic I. TBC1D5 and the AP2 complex regulate ATG9 trafficking and initiation of autophagy. EMBO Rep. 2014. 15 (4): 392-401. Link

Dikic I, Harper W, Hay R, Langer T, Rape M, Sixma T, Walczak H. The seven wonders of ubiquitin: a multi-interview: Personal insights into the ubiquitin field. Interview by Nonia Pariente. EMBO Rep. 2014. 15 (1): 7-11. Link

Piper RC, Dikic I, Lukacs GL. Ubiquitin-dependent sorting in endocytosis. Cold Spring Harb Perspect Biol 2014. 6 (1): . Link

Wild P, McEwan DG, Dikic I. The LC3 interactome at a glance. J. Cell. Sci. 2014. 127 (Pt 1): 3-9. Link

Putyrski M, Dikic I. Breaking the limits of artificial ubiquitination. Proc. Natl. Acad. Sci. U.S.A. 2013. 110 (44): 17606-7. Link

Stieglitz B, Rana RR, Koliopoulos MG, Morris-Davies AC, Schaeffer V, Christodoulou E, Howell S, Brown NR, Dikic I, Rittinger K. Structural basis for ligase-specific conjugation of linear ubiquitin chains by HOIP. Nature 2013. 503 (7476): 422-426. Link

van Wijk SJ, Fiškin E, Dikic I. Selective monitoring of ubiquitin signals with genetically encoded ubiquitin chain-specific sensors. Nat Protoc 2013. 8 (7): 1449-58. Link

Rogov VV, Suzuki H, Fiskin E, Wild P, Kniss A, Rozenknop A, Kato R, Kawasaki M, McEwan DG, Löhr F, Güntert P, Dikic I, Wakatsuki S, Dötsch V. Structural basis for phosphorylation-triggered autophagic clearance of Salmonella. Biochem. J. 2013. 454 (3): 459-66. Link

Carroll B, Mohd-Naim N, Maximiano F, Frasa MA, McCormack J, Finelli M, Thoresen SB, Perdios L, Daigaku R, Francis RE, Futter C, Dikic I, Braga VM. The TBC/RabGAP Armus coordinates Rac1 and Rab7 functions during autophagy. Dev. Cell 2013. 25 (1): 15-28. Link

Olma MH, Dikic I. Cullins getting undressed by the protein exchange factor Cand1. Cell 2013. 153 (1): 14-6. Link

Fiškin E, Dikic I. Parkin promotes cell survival via linear ubiquitination. EMBO J. 2013. 32 (8): 1072-4. Link

Crosetto N, Mitra A, Silva MJ, Bienko M, Dojer N, Wang Q, Karaca E, Chiarle R, Skrzypczak M, Ginalski K, Pasero P, Rowicka M, Dikic I. Nucleotide-resolution DNA double-strand break mapping by next-generation sequencing. Nat. Methods 2013. 10 (4): 361-5. Link

Zhu Y, Massen S, Terenzio M, Lang V, Chen-Lindner S, Eils R, Novak I, Dikic I, Hamacher-Brady A, Brady NR. Modulation of serines 17 and 24 in the LC3-interacting region of Bnip3 determines pro-survival mitophagy versus apoptosis. J. Biol. Chem. 2013. 288 (2): 1099-113. Link

Korac J, Schaeffer V, Kovacevic I, Clement AM, Jungblut B, Behl C, Terzic J, Dikic I. Ubiquitin-independent function of optineurin in autophagic clearance of protein aggregates. J. Cell. Sci. 2013. 126 (Pt 2): 580-92. Link

Verhelst K, Carpentier I, Kreike M, Meloni L, Verstrepen L, Kensche T, Dikic I, Beyaert R. A20 inhibits LUBAC-mediated NF-κB activation by binding linear polyubiquitin chains via its zinc finger 7. EMBO J. 2012. 31 (19): 3845-55. Link

Klionsky DJ, Abdalla FC, Abeliovich H, Abraham RT, Acevedo-Arozena A, Adeli K, Agholme L, Agnello M, Agostinis P, Aguirre-Ghiso JA, Ahn HJ, Ait-Mohamed O, Ait-Si-Ali S, Akematsu T, Akira S, Al-Younes HM, Al-Zeer MA, Albert ML, Albin RL, Alegre-Abarrategui J, Aleo MF, Alirezaei M, Almasan A, Almonte-Becerril M, Amano A, Amaravadi R, Amarnath S, Amer AO, Andrieu-Abadie N, Anantharam V, Ann DK, Anoopkumar-Dukie S, Aoki H, Apostolova N, Arancia G, Aris JP, Asanuma K, Asare NY, Ashida H, Askanas V, A.... Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy 2012. 8 (4): 445-544. Link

Rizvi H, Paterson JC, Tedoldi S, Ramsay A, Calaminici M, Natkunam Y, Lonardi S, Tan SY, Campbell L, Hansmann ML, Jones D, Dikic I, Shaw AS, Pileri SA, Stein H, Mason DY, Facchetti F, Marafioti T. Expression of the CD2AP adaptor molecule in normal, reactive and neoplastic human tissue. Pathologica 2012. 104 (2): 56-64. Link

Pohl C, Dikic I. Fighting mycobacteria through ISGylation. EMBO Rep. 2012. 13 (10): 872-3. Link

Belgnaoui SM, Paz S, Samuel S, Goulet ML, Sun Q, Kikkert M, Iwai K, Dikic I, Hiscott J, Lin R. Linear ubiquitination of NEMO negatively regulates the interferon antiviral response through disruption of the MAVS-TRAF3 complex. Cell Host Microbe 2012. 12 (2): 211-22. Link

van Wijk SJ, Fiskin E, Putyrski M, Pampaloni F, Hou J, Wild P, Kensche T, Grecco HE, Bastiaens P, Dikic I. Fluorescence-based sensors to monitor localization and functions of linear and K63-linked ubiquitin chains in cells. Mol. Cell 2012. 47 (5): 797-809. Link

Fulda S, Rajalingam K, Dikic I. Ubiquitylation in immune disorders and cancer: from molecular mechanisms to therapeutic implications. EMBO Mol Med 2012. 4 (7): 545-56. Link

Shaid S, Brandts CH, Serve H, Dikic I. Ubiquitination and selective autophagy. Cell Death Differ. 2013. 20 (1): 21-30. Link

Kensche T, Tokunaga F, Ikeda F, Goto E, Iwai K, Dikic I. Analysis of nuclear factor-κB (NF-κB) essential modulator (NEMO) binding to linear and lysine-linked ubiquitin chains and its role in the activation of NF-κB. J. Biol. Chem. 2012. 287 (28): 23626-34. Link

Rahighi S, Dikic I. Selectivity of the ubiquitin-binding modules. FEBS Lett. 2012. 586 (17): 2705-10. Link

Stieglitz B, Haire LF, Dikic I, Rittinger K. Structural analysis of SHARPIN, a subunit of a large multi-protein E3 ubiquitin ligase, reveals a novel dimerization function for the pleckstrin homology superfold. J. Biol. Chem. 2012. 287 (25): 20823-9. Link

Husnjak K, Dikic I. Ubiquitin-binding proteins: decoders of ubiquitin-mediated cellular functions. Annu. Rev. Biochem. 2012. 81 (): 291-322. Link

Rogov VV, Rozenknop A, Rogova NY, Löhr F, Tikole S, Jaravine V, Güntert P, Dikic I, Dötsch V. A universal expression tag for structural and functional studies of proteins. Chembiochem 2012. 13 (7): 959-63. Link

Walczak H, Iwai K, Dikic I. Generation and physiological roles of linear ubiquitin chains. BMC Biol. 2012. 10 (): 23. Link

Dikic I, Robertson M. Ubiquitin ligases and beyond. BMC Biol. 2012. 10 (): 22. Link

Dikic I. Ivan Dikic was trained as a medical doctor at the University of Zagreb, Croatia. Curr. Biol. 2012. 22 (3): R76-7. Link

Haglund K, Dikic I. The role of ubiquitylation in receptor endocytosis and endosomal sorting. J. Cell. Sci. 2012. 125 (Pt 2): 265-75. Link

Popovic D, Akutsu M, Novak I, Harper JW, Behrends C, Dikic I. Rab GTPase-activating proteins in autophagy: regulation of endocytic and autophagy pathways by direct binding to human ATG8 modifiers. Mol. Cell. Biol. 2012. 32 (9): 1733-44. Link

Dikic I, Daly RJ. Signalling through the grapevine. EMBO Rep. 2012. 13 (3): 178-80. Link

van Wijk SJ, Bienko M, Dikic I. Role of UbL family modifiers and their binding proteins in cell signaling. Methods Mol. Biol. 2012. 832 (): 163-71. Link

Rohaim A, Kawasaki M, Kato R, Dikic I, Wakatsuki S. Structure of a compact conformation of linear diubiquitin. Acta Crystallogr. D Biol. Crystallogr. 2012. 68 (Pt 2): 102-8. Link

Pareja F, Ferraro DA, Rubin C, Cohen-Dvashi H, Zhang F, Aulmann S, Ben-Chetrit N, Pines G, Navon R, Crosetto N, Köstler W, Carvalho S, Lavi S, Schmitt F, Dikic I, Yakhini Z, Sinn P, Mills GB, Yarden Y. Deubiquitination of EGFR by Cezanne-1 contributes to cancer progression. Oncogene 2012. 31 (43): 4599-608. Link

Sandilands E, Serrels B, McEwan DG, Morton JP, Macagno JP, McLeod K, Stevens C, Brunton VG, Langdon WY, Vidal M, Sansom OJ, Dikic I, Wilkinson S, Frame MC. Autophagic targeting of Src promotes cancer cell survival following reduced FAK signalling. Nat. Cell Biol. 2011. 14 (1): 51-60. Link

van Wijk SJ, Müller S, Dikic I. Shared and unique properties of ubiquitin and SUMO interaction networks in DNA repair. Genes Dev. 2011. 25 (17): 1763-9. Link

Rahighi S, Dikic I. Conformational flexibility and rotation of the RING domain in activation of cullin-RING ligases. Nat. Struct. Mol. Biol. 2011. 18 (8): 863-5. Link

Rajalingam K, Dikic I. Healthy ageing through regulated proteostasis. EMBO J. 2011. 30 (15): 2983-5. Link

Rozenknop A, Rogov VV, Rogova NY, Löhr F, Güntert P, Dikic I, Dötsch V. Characterization of the interaction of GABARAPL-1 with the LIR motif of NBR1. J. Mol. Biol. 2011. 410 (3): 477-87. Link

Wild P, Farhan H, McEwan DG, Wagner S, Rogov VV, Brady NR, Richter B, Korac J, Waidmann O, Choudhary C, Dötsch V, Bumann D, Dikic I. Phosphorylation of the autophagy receptor optineurin restricts Salmonella growth. Science 2011. 333 (6039): 228-33. Link

Ikeda F, Deribe YL, Skånland SS, Stieglitz B, Grabbe C, Franz-Wachtel M, van Wijk SJ, Goswami P, Nagy V, Terzic J, Tokunaga F, Androulidaki A, Nakagawa T, Pasparakis M, Iwai K, Sundberg JP, Schaefer L, Rittinger K, Macek B, Dikic I. SHARPIN forms a linear ubiquitin ligase complex regulating NF-κB activity and apoptosis. Nature 2011. 471 (7340): 637-41. Link

Grabbe C, Husnjak K, Dikic I. The spatial and temporal organization of ubiquitin networks. Nat. Rev. Mol. Cell Biol. 2011. 12 (5): 295-307. Link

Mendl N, Occhipinti A, Müller M, Wild P, Dikic I, Reichert AS. Mitophagy in yeast is independent of mitochondrial fission and requires the stress response gene WHI2. J. Cell. Sci. 2011. 124 (Pt 8): 1339-50. Link

McEwan DG, Dikic I. The Three Musketeers of Autophagy: phosphorylation, ubiquitylation and acetylation. Trends Cell Biol. 2011. 21 (4): 195-201. Link

Hoeller D, Dikic I. Regulation of ubiquitin receptors by coupled monoubiquitination. Subcell. Biochem. 2010. 54 (): 31-40. Link

Novak I, Dikic I. Autophagy receptors in developmental clearance of mitochondria. Autophagy 2011. 7 (3): 301-3. Link

Ikeda F, Rahighi S, Wakatsuki S, Dikic I. Selective binding of linear ubiquitin chains to NEMO in NF-kappaB activation. Adv. Exp. Med. Biol. 2011. 691 (): 107-14. Link

Ikeda F, Crosetto N, Dikic I. What determines the specificity and outcomes of ubiquitin signaling? Cell 2010. 143 (5): 677-81. Link

Kirkin V, Dikic I. Ubiquitin networks in cancer. Curr. Opin. Genet. Dev. 2011. 21 (1): 21-8. Link

Suzuki N, Hiraki M, Yamada Y, Matsugaki N, Igarashi N, Kato R, Dikic I, Drew D, Iwata S, Wakatsuki S, Kawasaki M. Crystallization of small proteins assisted by green fluorescent protein. Acta Crystallogr. D Biol. Crystallogr. 2010. 66 (Pt 10): 1059-66. Link

Bethani I, Skånland SS, Dikic I, Acker-Palmer A. Spatial organization of transmembrane receptor signalling. EMBO J. 2010. 29 (16): 2677-88. Link

Shimokawa N, Haglund K, Hölter SM, Grabbe C, Kirkin V, Koibuchi N, Schultz C, Rozman J, Hoeller D, Qiu CH, Londoño MB, Ikezawa J, Jedlicka P, Stein B, Schwarzacher SW, Wolfer DP, Ehrhardt N, Heuchel R, Nezis I, Brech A, Schmidt MHH, Fuchs H, Gailus-Durner V, Klingenspor M, Bogler O, Wurst W, Deller T, de Angelis MH, Dikic I. CIN85 regulates dopamine receptor endocytosis and governs behaviour in mice. EMBO J. 2010. 29 (14): 2421-32. Link

Deribe YL, Pawson T, Dikic I. Post-translational modifications in signal integration. Nat. Struct. Mol. Biol. 2010. 17 (6): 666-72. Link

Dikic I, Schmidt MHH. Notch: Implications of endogenous inhibitors for therapy. Bioessays 2010. 32 (6): 481-487. Link

McEwan DG, Dikic I. Not all autophagy membranes are created equal. Cell 2010. 141 (4): 564-6. Link

Haglund K, Nezis IP, Lemus D, Grabbe C, Wesche J, Liestøl K, Dikic I, Palmer R, Stenmark H. Cindr interacts with anillin to control cytokinesis in Drosophila melanogaster. Curr. Biol. 2010. 20 (10): 944-50. Link

Dikic I, Johansen T, Kirkin V. Selective autophagy in cancer development and therapy. Cancer Res. 2010. 70 (9): 3431-4. Link

Vivanco I, Rohle D, Versele M, Iwanami A, Kuga D, Oldrini B, Tanaka K, Dang J, Kubek S, Palaskas N, Hsueh T, Evans M, Mulholland D, Wolle D, Rajasekaran S, Rajasekaran A, Liau LM, Cloughesy TF, Dikic I, Brennan C, Wu H, Mischel PS, Perera T, Mellinghoff IK. The phosphatase and tensin homolog regulates epidermal growth factor receptor (EGFR) inhibitor response by targeting EGFR for degradation. Proc. Natl. Acad. Sci. U.S.A. 2010. 107 (14): 6459-64. Link

Bomar MG, D'Souza S, Bienko M, Dikic I, Walker GC, Zhou P. Unconventional ubiquitin recognition by the ubiquitin-binding motif within the Y family DNA polymerases iota and Rev1. Mol. Cell 2010. 37 (3): 408-17. Link

Bienko M, Green CM, Sabbioneda S, Crosetto N, Matic I, Hibbert RG, Begovic T, Niimi A, Mann M, Lehmann AR, Dikic I. Regulation of translesion synthesis DNA polymerase eta by monoubiquitination. Mol. Cell 2010. 37 (3): 396-407. Link

Wild P, Dikic I. Mitochondria get a Parkin' ticket. Nat. Cell Biol. 2010. 12 (2): 104-6. Link

Nagy V, Dikic I. Ubiquitin ligase complexes: from substrate selectivity to conjugational specificity. Biol. Chem. . 391 (2-3): 163-9. Link

Deribe YL, Wild P, Chandrashaker A, Curak J, Schmidt MHH, Kalaidzidis Y, Milutinovic N, Kratchmarova I, Buerkle L, Fetchko MJ, Schmidt P, Kittanakom S, Brown KR, Jurisica I, Blagoev B, Zerial M, Stagljar I, Dikic I. Regulation of epidermal growth factor receptor trafficking by lysine deacetylase HDAC6. Sci Signal 2009. 2 (102): ra84. Link

Novak I, Kirkin V, McEwan DG, Zhang J, Wild P, Rozenknop A, Rogov V, Löhr F, Popovic D, Occhipinti A, Reichert AS, Terzic J, Dötsch V, Ney PA, Dikic I. Nix is a selective autophagy receptor for mitochondrial clearance. EMBO Rep. 2010. 11 (1): 45-51. Link

Dikic I, Dötsch V. Ubiquitin linkages make a difference. Nat. Struct. Mol. Biol. 2009. 16 (12): 1209-10. Link

Dikic I, Wakatsuki S, Walters KJ. Ubiquitin-binding domains - from structures to functions. Nat. Rev. Mol. Cell Biol. 2009. 10 (10): 659-71. Link

Lappe-Siefke C, Loebrich S, Hevers W, Waidmann OB, Schweizer M, Fehr S, Fritschy JM, Dikic I, Eilers J, Wilson SM, Kneussel M. The ataxia (axJ) mutation causes abnormal GABAA receptor turnover in mice. PLoS Genet. 2009. 5 (9): e1000631. Link

Schmidt MHH, Bicker F, Nikolic I, Meister J, Babuke T, Picuric S, Müller-Esterl W, Plate KH, Dikic I. Epidermal growth factor-like domain 7 (EGFL7) modulates Notch signalling and affects neural stem cell renewal. Nat. Cell Biol. 2009. 11 (7): 873-80. Link

Lamark T, Kirkin V, Dikic I, Johansen T. NBR1 and p62 as cargo receptors for selective autophagy of ubiquitinated targets. Cell Cycle 2009. 8 (13): 1986-90. Link

Kirkin V, McEwan DG, Novak I, Dikic I. A role for ubiquitin in selective autophagy. Mol. Cell 2009. 34 (3): 259-69. Link

Kirkin V, Lamark T, Johansen T, Dikic I. NBR1 cooperates with p62 in selective autophagy of ubiquitinated targets. Autophagy 2009. 5 (5): 732-3. Link

Dikic I. Journal club. A new ubiquitin chain, a new signal. Nat. Rev. Mol. Cell Biol. 2009. 10 (5): 306. Link

Hoeller D, Dikic I. Targeting the ubiquitin system in cancer therapy. Nature 2009. 458 (7237): 438-44. Link

Rahighi S, Ikeda F, Kawasaki M, Akutsu M, Suzuki N, Kato R, Kensche T, Uejima T, Bloor S, Komander D, Randow F, Wakatsuki S, Dikic I. Specific recognition of linear ubiquitin chains by NEMO is important for NF-kappaB activation. Cell 2009. 136 (6): 1098-109. Link

Grabbe C, Dikic I. Functional roles of ubiquitin-like domain (ULD) and ubiquitin-binding domain (UBD) containing proteins. Chem. Rev. 2009. 109 (4): 1481-94. Link

Kirkin V, Lamark T, Sou YS, Bjørkøy G, Nunn JL, Bruun JA, Shvets E, McEwan DG, Clausen TH, Wild P, Bilusic I, Theurillat JP, Øvervatn A, Ishii T, Elazar Z, Komatsu M, Dikic I, Johansen T. A role for NBR1 in autophagosomal degradation of ubiquitinated substrates. Mol. Cell 2009. 33 (4): 505-16. Link

Sabbioneda S, Green CM, Bienko M, Kannouche P, Dikic I, Lehmann AR. Ubiquitin-binding motif of human DNA polymerase eta is required for correct localization. Proc. Natl. Acad. Sci. U.S.A. 2009. 106 (8): E20; author reply E21. Link

Scharner D, Rössig L, Carmona G, Chavakis E, Urbich C, Fischer A, Kang TB, Wallach D, Chiang YJ, Deribe YL, Dikic I, Zeiher AM, Dimmeler S. Caspase-8 is involved in neovascularization-promoting progenitor cell functions. Arterioscler. Thromb. Vasc. Biol. 2009. 29 (4): 571-8. Link

Rajalingam K, Dikic I. Inhibitors of apoptosis catch ubiquitin. Biochem. J. 2009. 417 (1): e1-3. Link

Grabbe C, Dikic I. Cell biology. Going global on ubiquitin. Science 2008. 322 (5903): 872-3. Link

Crosetto N, Bienko M, Hibbert RG, Perica T, Ambrogio C, Kensche T, Hofmann K, Sixma TK, Dikic I. Human Wrnip1 is localized in replication factories in a ubiquitin-binding zinc finger-dependent manner. J. Biol. Chem. 2008. 283 (50): 35173-85. Link

Jozic D, Cárdenes N, Deribe YL, Moncalián G, Hoeller D, Groemping Y, Dikic I, Rittinger K, Bravo J. Reply to "The binding stoichiometry of CIN85 SH3 domain A and Cbl-b". Nat. Struct. Mol. Biol. 2008. 15 (9): 891-2. Link

Nonis D, Schmidt MHH, van de Loo S, Eich F, Dikic I, Nowock J, Auburger G. Ataxin-2 associates with the endocytosis complex and affects EGF receptor trafficking. Cell. Signal. 2008. 20 (10): 1725-39. Link

Ikeda F, Dikic I. Atypical ubiquitin chains: new molecular signals. 'Protein Modifications: Beyond the Usual Suspects' review series. EMBO Rep. 2008. 9 (6): 536-42. Link

Schreiner P, Chen X, Husnjak K, Randles L, Zhang N, Elsasser S, Finley D, Dikic I, Walters KJ, Groll M. Ubiquitin docking at the proteasome through a novel pleckstrin-homology domain interaction. Nature 2008. 453 (7194): 548-52. Link

Husnjak K, Elsasser S, Zhang N, Chen X, Randles L, Shi Y, Hofmann K, Walters KJ, Finley D, Dikic I. Proteasome subunit Rpn13 is a novel ubiquitin receptor. Nature 2008. 453 (7194): 481-8. Link

Schmidt-Glenewinkel H, Vacheva I, Hoeller D, Dikic I, Eils R. An ultrasensitive sorting mechanism for EGF receptor endocytosis. BMC Syst Biol 2008. 2 (): 32. Link

Zagrovic B, Dikic I. Childhood of a phoenix: modern biology in Eastern and South-Eastern Europe. Nat. Rev. Mol. Cell Biol. 2008. 9 (4): 333-6. Link

Iha H, Peloponese JM, Verstrepen L, Zapart G, Ikeda F, Smith CD, Starost MF, Yedavalli V, Heyninck K, Dikic I, Beyaert R, Jeang KT. Inflammatory cardiac valvulitis in TAX1BP1-deficient mice through selective NF-kappaB activation. EMBO J. 2008. 27 (4): 629-41. Link

Marafioti T, Paterson JC, Ballabio E, Reichard KK, Tedoldi S, Hollowood K, Dictor M, Hansmann ML, Pileri SA, Dyer MJ, Sozzani S, Dikic I, Shaw AS, Petrella T, Stein H, Isaacson PG, Facchetti F, Mason DY. Novel markers of normal and neoplastic human plasmacytoid dendritic cells. Blood 2008. 111 (7): 3778-92. Link

Bloor S, Ryzhakov G, Wagner S, Butler PJ, Smith DL, Krumbach R, Dikic I, Randow F. Signal processing by its coil zipper domain activates IKK gamma. Proc. Natl. Acad. Sci. U.S.A. 2008. 105 (4): 1279-84. Link

Wagner S, Carpentier I, Rogov V, Kreike M, Ikeda F, Löhr F, Wu CJ, Ashwell JD, Dötsch V, Dikic I, Beyaert R. Ubiquitin binding mediates the NF-kappaB inhibitory potential of ABIN proteins. Oncogene 2008. 27 (26): 3739-45. Link

Guo C, Tang TS, Bienko M, Dikic I, Friedberg EC. Requirements for the interaction of mouse Polkappa with ubiquitin and its biological significance. J. Biol. Chem. 2008. 283 (8): 4658-64. Link

Terzic J, Marinovic-Terzic I, Ikeda F, Dikic I. Ubiquitin signals in the NF-kappaB pathway. Biochem. Soc. Trans. 2007. 35 (Pt 5): 942-5. Link

Raguz J, Wagner S, Dikic I, Hoeller D. Suppressor of T-cell receptor signalling 1 and 2 differentially regulate endocytosis and signalling of receptor tyrosine kinases. FEBS Lett. 2007. 581 (24): 4767-72. Link

Ikeda F, Hecker CM, Rozenknop A, Nordmeier RD, Rogov V, Hofmann K, Akira S, Dötsch V, Dikic I. Involvement of the ubiquitin-like domain of TBK1/IKK-i kinases in regulation of IFN-inducible genes. EMBO J. 2007. 26 (14): 3451-62. Link

Hoeller D, Hecker CM, Wagner S, Rogov V, Dötsch V, Dikic I. E3-independent monoubiquitination of ubiquitin-binding proteins. Mol. Cell 2007. 26 (6): 891-8. Link

Dikic I, Schmidt MHH. Malfunctions within the Cbl interactome uncouple receptor tyrosine kinases from destructive transport. Eur. J. Cell Biol. 2007. 86 (9): 505-12. Link

Sargin B, Choudhary C, Crosetto N, Schmidt MHH, Grundler R, Rensinghoff M, Thiessen C, Tickenbrock L, Schwäble J, Brandts C, August B, Koschmieder S, Bandi SR, Duyster J, Berdel WE, Müller-Tidow C, Dikic I, Serve H. Flt3-dependent transformation by inactivating c-Cbl mutations in AML. Blood 2007. 110 (3): 1004-12. Link

Kirkin V, Dikic I. Role of ubiquitin- and Ubl-binding proteins in cell signaling. Curr. Opin. Cell Biol. 2007. 19 (2): 199-205. Link

Parker JL, Bielen AB, Dikic I, Ulrich HD. Contributions of ubiquitin- and PCNA-binding domains to the activity of Polymerase eta in Saccharomyces cerevisiae. Nucleic Acids Res. 2007. 35 (3): 881-9. Link

Tossidou I, Kardinal C, Peters I, Kriz W, Shaw A, Dikic I, Tkachuk S, Dumler I, Haller H, Schiffer M. CD2AP/CIN85 balance determines receptor tyrosine kinase signaling response in podocytes. J. Biol. Chem. 2007. 282 (10): 7457-64. Link

Crosetto N, Bienko M, Dikic I. Ubiquitin hubs in oncogenic networks. Mol. Cancer Res. 2006. 4 (12): 899-904. Link

Schmidt MHH, Dikic I. Ubiquitin and NEDD8: brothers in arms. Sci. STKE 2006. 2006 (362): .pe50. Link

Dikic I, Crosetto N, Calatroni S, Bernasconi P. Targeting ubiquitin in cancers. Eur. J. Cancer 2006. 42 (18): 3095-102. Link

Moncalián G, Cárdenes N, Deribe YL, Spínola-Amilibia M, Dikic I, Bravo J. Atypical polyproline recognition by the CMS N-terminal Src homology 3 domain. J. Biol. Chem. 2006. 281 (50): 38845-53. Link

Hoeller D, Hecker CM, Dikic I. Ubiquitin and ubiquitin-like proteins in cancer pathogenesis. Nat. Rev. Cancer 2006. 6 (10): 776-88. Link

Guo C, Tang TS, Bienko M, Parker JL, Bielen AB, Sonoda E, Takeda S, Ulrich HD, Dikic I, Friedberg EC. Ubiquitin-binding motifs in REV1 protein are required for its role in the tolerance of DNA damage. Mol. Cell. Biol. 2006. 26 (23): 8892-900. Link

Husnjak K, Dikic I. EGFR trafficking: parkin' in a jam. Nat. Cell Biol. 2006. 8 (8): 787-8. Link

Seet BT, Dikic I, Zhou MM, Pawson T. Reading protein modifications with interaction domains. Nat. Rev. Mol. Cell Biol. 2006. 7 (7): 473-83. Link

Schmidt MHH, Dikic I. Assays to monitor degradation of the EGF receptor. Methods Mol. Biol. 2006. 327 (): 131-8. Link

Ikeda F, Dikic I. CYLD in ubiquitin signaling and tumor pathogenesis. Cell 2006. 125 (4): 643-5. Link

Hecker CM, Rabiller M, Haglund K, Bayer P, Dikic I. Specification of SUMO1- and SUMO2-interacting motifs. J. Biol. Chem. 2006. 281 (23): 16117-27. Link

Hoeller D, Crosetto N, Blagoev B, Raiborg C, Tikkanen R, Wagner S, Kowanetz K, Breitling R, Mann M, Stenmark H, Dikic I. Regulation of ubiquitin-binding proteins by monoubiquitination. Nat. Cell Biol. 2006. 8 (2): 163-9. Link

Schmidt MHH, Husnjak K, Szymkiewicz I, Haglund K, Dikic I. Cbl escapes Cdc42-mediated inhibition by downregulation of the adaptor molecule betaPix. Oncogene 2006. 25 (21): 3071-8. Link

Katic M, Bosnjak B, Gall-Troselj K, Dikic I, Pavelic K. A clinoptilolite effect on cell media and the consequent effects on tumor cells in vitro. Front. Biosci. 2006. 11 (): 1722-32. Link

Bienko M, Green CM, Crosetto N, Rudolf F, Zapart G, Coull B, Kannouche P, Wider G, Peter M, Lehmann AR, Hofmann K, Dikic I. Ubiquitin-binding domains in Y-family polymerases regulate translesion synthesis. Science 2005. 310 (5755): 1821-4. Link

Aissouni Y, Zapart G, Iovanna JL, Dikic I, Soubeyran P. CIN85 regulates the ability of MEKK4 to activate the p38 MAP kinase pathway. Biochem. Biophys. Res. Commun. 2005. 338 (2): 808-14. Link

Jozic D, Cárdenes N, Deribe YL, Moncalián G, Hoeller D, Groemping Y, Dikic I, Rittinger K, Bravo J. Cbl promotes clustering of endocytic adaptor proteins. Nat. Struct. Mol. Biol. 2005. 12 (11): 972-9. Link

Schmidt MHH, Dikic I. The Cbl interactome and its functions. Nat. Rev. Mol. Cell Biol. 2005. 6 (12): 907-18. Link

Molfetta R, Belleudi F, Peruzzi G, Morrone S, Leone L, Dikic I, Piccoli M, Frati L, Torrisi MR, Santoni A, Paolini R. CIN85 regulates the ligand-dependent endocytosis of the IgE receptor: a new molecular mechanism to dampen mast cell function. J. Immunol. 2005. 175 (7): 4208-16. Link

Haglund K, Dikic I. Ubiquitylation and cell signaling. EMBO J. 2005. 24 (19): 3353-9. Link

Eckerdt F, Yuan J, Saxena K, Martin B, Kappel S, Lindenau C, Kramer A, Naumann S, Daum S, Fischer G, Dikic I, Kaufmann M, Strebhardt K. Polo-like kinase 1-mediated phosphorylation stabilizes Pin1 by inhibiting its ubiquitination in human cells. J. Biol. Chem. 2005. 280 (44): 36575-83. Link

Sulić S, Panić L, Dikić I, Volarević S. Deregulation of cell growth and malignant transformation. Croat. Med. J. 2005. 46 (4): 622-38. Link

Haglund K, Schmidt MHH, Wong ES, Guy GR, Dikic I. Sprouty2 acts at the Cbl/CIN85 interface to inhibit epidermal growth factor receptor downregulation. EMBO Rep. 2005. 6 (7): 635-41. Link

Crosetto N, Tikkanen R, Dikic I. Oncogenic breakdowns in endocytic adaptor proteins. FEBS Lett. 2005. 579 (15): 3231-8. Link

Hoeller D, Volarevic S, Dikic I. Compartmentalization of growth factor receptor signalling. Curr. Opin. Cell Biol. 2005. 17 (2): 107-11. Link

Shimokawa N, Dikic I, Sugama S, Koibuchi N. Molecular responses to acidosis of central chemosensitive neurons in brain. Cell. Signal. 2005. 17 (7): 799-808. Link

Banno Y, Ohguchi K, Matsumoto N, Koda M, Ueda M, Hara A, Dikic I, Nozawa Y. Implication of phospholipase D2 in oxidant-induced phosphoinositide 3-kinase signaling via Pyk2 activation in PC12 cells. J. Biol. Chem. 2005. 280 (16): 16319-24. Link

Schmidt MHH, Dikic I, Bögler O. Src phosphorylation of Alix/AIP1 modulates its interaction with binding partners and antagonizes its activities. J. Biol. Chem. 2005. 280 (5): 3414-25. Link

Schmidt MHH, Hoeller D, Yu J, Furnari FB, Cavenee WK, Dikic I, Bögler O. Alix/AIP1 antagonizes epidermal growth factor receptor downregulation by the Cbl-SETA/CIN85 complex. Mol. Cell. Biol. 2004. 24 (20): 8981-93. Link

Szymkiewicz I, Shupliakov O, Dikic I. Cargo- and compartment-selective endocytic scaffold proteins. Biochem. J. 2004. 383 (Pt 1): 1-11. Link

Dikic I. ALIX-ing phospholipids with endosome biogenesis. Bioessays 2004. 26 (6): 604-7. Link

Kowanetz K, Crosetto N, Haglund K, Schmidt MHH, Heldin CH, Dikic I. Suppressors of T-cell receptor signaling Sts-1 and Sts-2 bind to Cbl and inhibit endocytosis of receptor tyrosine kinases. J. Biol. Chem. 2004. 279 (31): 32786-95. Link

Szymkiewicz I, Destaing O, Jurdic P, Dikic I. SH3P2 in complex with Cbl and Src. FEBS Lett. 2004. 565 (1-3): 33-8. Link

Haglund K, Ivankovic-Dikic I, Shimokawa N, Kruh GD, Dikic I. Recruitment of Pyk2 and Cbl to lipid rafts mediates signals important for actin reorganization in growing neurites. J. Cell. Sci. 2004. 117 (Pt 12): 2557-68. Link

Shimokawa N, Qiu CH, Seki T, Dikic I, Koibuchi N. Phosphorylation of JNK is involved in regulation of H(+)-induced c-Jun expression. Cell. Signal. 2004. 16 (6): 723-9. Link

Kowanetz K, Husnjak K, Höller D, Kowanetz M, Soubeyran P, Hirsch D, Schmidt MHH, Pavelic K, De Camilli P, Randazzo PA, Dikic I. CIN85 associates with multiple effectors controlling intracellular trafficking of epidermal growth factor receptors. Mol. Biol. Cell 2004. 15 (7): 3155-66. Link

Höller D, Dikic I. Receptor endocytosis via ubiquitin-dependent and -independent pathways. Biochem. Pharmacol. 2004. 67 (6): 1013-7. Link

Dikic I. Mechanisms controlling EGF receptor endocytosis and degradation. Biochem. Soc. Trans. 2003. 31 (Pt 6): 1178-81. Link

Haglund K, Di Fiore PP, Dikic I. Distinct monoubiquitin signals in receptor endocytosis. Trends Biochem. Sci. 2003. 28 (11): 598-603. Link

Kowanetz K, Terzic J, Dikic I. Dab2 links CIN85 with clathrin-mediated receptor internalization. FEBS Lett. 2003. 554 (1-2): 81-7. Link

Dikic I, Szymkiewicz I, Soubeyran P. Cbl signaling networks in the regulation of cell function. Cell. Mol. Life Sci. 2003. 60 (9): 1805-27. Link

Kowanetz K, Szymkiewicz I, Haglund K, Kowanetz M, Husnjak K, Taylor JD, Soubeyran P, Engstrom U, Ladbury JE, Dikic I. Identification of a novel proline-arginine motif involved in CIN85-dependent clustering of Cbl and down-regulation of epidermal growth factor receptors. J. Biol. Chem. 2003. 278 (41): 39735-46. Link

Haglund K, Sigismund S, Polo S, Szymkiewicz I, Di Fiore PP, Dikic I. Multiple monoubiquitination of RTKs is sufficient for their endocytosis and degradation. Nat. Cell Biol. 2003. 5 (5): 461-6. Link

Dikic I, Giordano S. Negative receptor signalling. Curr. Opin. Cell Biol. 2003. 15 (2): 128-35. Link

Piiper A, Lutz MP, Cramer H, Elez R, Kronenberger B, Dikic I, Müller-Esterl W, Zeuzem S. Protein kinase A mediates cAMP-induced tyrosine phosphorylation of the epidermal growth factor receptor. Biochem. Biophys. Res. Commun. 2003. 301 (4): 848-54. Link

Soubeyran P, Barac A, Szymkiewicz I, Dikic I. Cbl-ArgBP2 complex mediates ubiquitination and degradation of c-Abl. Biochem. J. 2003. 370 (Pt 1): 29-34. Link

Shimokawa N, Okada J, Haglund K, Dikic I, Koibuchi N, Miura M. Past-A, a novel proton-associated sugar transporter, regulates glucose homeostasis in the brain. J. Neurosci. 2002. 22 (21): 9160-5. Link

Dikic I. CIN85/CMS family of adaptor molecules. FEBS Lett. 2002. 529 (1): 110-5. Link

Haglund K, Shimokawa N, Szymkiewicz I, Dikic I. Cbl-directed monoubiquitination of CIN85 is involved in regulation of ligand-induced degradation of EGF receptors. Proc. Natl. Acad. Sci. U.S.A. 2002. 99 (19): 12191-6. Link

Piiper A, Dikic I, Lutz MP, Leser J, Kronenberger B, Elez R, Cramer H, Müller-Esterl W, Zeuzem S. Cyclic AMP induces transactivation of the receptors for epidermal growth factor and nerve growth factor, thereby modulating activation of MAP kinase, Akt, and neurite outgrowth in PC12 cells. J. Biol. Chem. 2002. 277 (46): 43623-30. Link

Szymkiewicz I, Kowanetz K, Soubeyran P, Dinarina A, Lipkowitz S, Dikic I. CIN85 participates in Cbl-b-mediated down-regulation of receptor tyrosine kinases. J. Biol. Chem. 2002. 277 (42): 39666-72. Link

Soubeyran P, Kowanetz K, Szymkiewicz I, Langdon WY, Dikic I. Cbl-CIN85-endophilin complex mediates ligand-induced downregulation of EGF receptors. Nature 2002. 416 (6877): 183-7. Link

Sajan MP, Bandyopadhyay G, Kanoh Y, Standaert ML, Quon MJ, Reed BC, Dikic I, Farese RV. Sorbitol activates atypical protein kinase C and GLUT4 glucose transporter translocation/glucose transport through proline-rich tyrosine kinase-2, the extracellular signal-regulated kinase pathway and phospholipase D. Biochem. J. 2002. 362 (Pt 3): 665-74. Link

Picascia A, Stanzione R, Chieffi P, Kisslinger A, Dikic I, Tramontano D. Proline-rich tyrosine kinase 2 regulates proliferation and differentiation of prostate cells. Mol. Cell. Endocrinol. 2002. 186 (1): 81-7. Link

Pizard A, Blaukat A, Michineau S, Dikic I, Müller-Esterl W, Alhenc-Gelas F, Rajerison RM. Palmitoylation of the human bradykinin B2 receptor influences ligand efficacy. Biochemistry 2001. 40 (51): 15743-51. Link

Blaukat A, Pizard A, Breit A, Wernstedt C, Alhenc-Gelas F, Muller-Esterl W, Dikic I. Determination of bradykinin B2 receptor in vivo phosphorylation sites and their role in receptor function. J. Biol. Chem. 2001. 276 (44): 40431-40. Link

Soubeyran P, Haglund K, Garcia S, Barth BU, Iovanna J, Dikic I. Homeobox gene Cdx1 regulates Ras, Rho and PI3 kinase pathways leading to transformation and tumorigenesis of intestinal epithelial cells. Oncogene 2001. 20 (31): 4180-7. Link

Bandyopadhyay G, Sajan MP, Kanoh Y, Standaert ML, Quon MJ, Reed BC, Dikic I, Farese RV. Glucose activates protein kinase C-zeta /lambda through proline-rich tyrosine kinase-2, extracellular signal-regulated kinase, and phospholipase D: a novel mechanism for activating glucose transporter translocation. J. Biol. Chem. 2001. 276 (38): 35537-45. Link

Pavelić K, Hadzija M, Bedrica L, Pavelić J, Dikić I, Katić M, Kralj M, Bosnar MH, Kapitanović S, Poljak-Blazi M, Krizanac S, Stojković R, Jurin M, Subotić B, Colić M. Natural zeolite clinoptilolite: new adjuvant in anticancer therapy. J. Mol. Med. 2001. 78 (12): 708-20. Link

Blaukat A, Dikic I. Activation of sphingosine kinase by the bradykinin B2 receptor and its implication in regulation of the ERK/MAP kinase pathway. Biol. Chem. 2001. 382 (1): 135-9. Link

Bandyopadhyay G, Sajan MP, Kanoh Y, Standaert ML, Burke TR, Quon MJ, Reed BC, Dikic I, Noel LE, Newgard CB, Farese R. Glucose activates mitogen-activated protein kinase (extracellular signal-regulated kinase) through proline-rich tyrosine kinase-2 and the Glut1 glucose transporter. J. Biol. Chem. 2000. 275 (52): 40817-26. Link

Ivankovic-Dikic I, Grönroos E, Blaukat A, Barth BU, Dikic I. Pyk2 and FAK regulate neurite outgrowth induced by growth factors and integrins. Nat. Cell Biol. 2000. 2 (9): 574-81. Link

Blaukat A, Barac A, Cross MJ, Offermanns S, Dikic I. G protein-coupled receptor-mediated mitogen-activated protein kinase activation through cooperation of Galpha(q) and Galpha(i) signals. Mol. Cell. Biol. 2000. 20 (18): 6837-48. Link

Sasaki A, Yasukawa H, Shouda T, Kitamura T, Dikic I, Yoshimura A. CIS3/SOCS-3 suppresses erythropoietin (EPO) signaling by binding the EPO receptor and JAK2. J. Biol. Chem. 2000. 275 (38): 29338-47. Link

Soubeyran P, André F, Lissitzky JC, Mallo GV, Moucadel V, Roccabianca M, Rechreche H, Marvaldi J, Dikic I, Dagorn JC, Iovanna JL. Cdx1 promotes differentiation in a rat intestinal epithelial cell line. Gastroenterology 1999. 117 (6): 1326-38. Link

Dikić I, Pavelić K. Dubrovnik Conference on Signal Transduction: an opportunity for education of young scientists. Acta Med Croatica 1999. 53 (1): 1-4. Link

Dikic I, Blaukat A. Protein tyrosine kinase-mediated pathways in G protein-coupled receptor signaling. Cell Biochem. Biophys. 1999. 30 (3): 369-87. Link

Blaukat A, Pizard A, Rajerison RM, Alhenc-Gelas F, Müller-Esterl W, Dikic I. Activation of mitogen-activated protein kinase by the bradykinin B2 receptor is independent of receptor phosphorylation and phosphorylation-triggered internalization. FEBS Lett. 1999. 451 (3): 337-41. Link

Blaukat A, Ivankovic-Dikic I, Grönroos E, Dolfi F, Tokiwa G, Vuori K, Dikic I. Adaptor proteins Grb2 and Crk couple Pyk2 with activation of specific mitogen-activated protein kinase cascades. J. Biol. Chem. 1999. 274 (21): 14893-901. Link

Yamashita H, Avraham S, Jiang S, Dikic I, Avraham H. The Csk homologous kinase associates with TrkA receptors and is involved in neurite outgrowth of PC12 cells. J. Biol. Chem. 1999. 274 (21): 15059-65. Link

Dikic I, Dikic I, Schlessinger J. Identification of a new Pyk2 isoform implicated in chemokine and antigen receptor signaling. J. Biol. Chem. 1998. 273 (23): 14301-8. Link

Miyazaki T, Takaoka A, Nogueira L, Dikic I, Fujii H, Tsujino S, Mitani Y, Maeda M, Schlessinger J, Taniguchi T. Pyk2 is a downstream mediator of the IL-2 receptor-coupled Jak signaling pathway. Genes Dev. 1998. 12 (6): 770-5. Link

Davis CB, Dikic I, Unutmaz D, Hill CM, Arthos J, Siani MA, Thompson DA, Schlessinger J, Littman DR. Signal transduction due to HIV-1 envelope interactions with chemokine receptors CXCR4 or CCR5. J. Exp. Med. 1997. 186 (10): 1793-8. Link

Qian D, Lev S, van Oers NS, Dikic I, Schlessinger J, Weiss A. Tyrosine phosphorylation of Pyk2 is selectively regulated by Fyn during TCR signaling. J. Exp. Med. 1997. 185 (7): 1253-9. Link

Dikic I, Tokiwa G, Lev S, Courtneidge SA, Schlessinger J. A role for Pyk2 and Src in linking G-protein-coupled receptors with MAP kinase activation. Nature 1996. 383 (6600): 547-50. Link

Tokiwa G, Dikic I, Lev S, Schlessinger J. Activation of Pyk2 by stress signals and coupling with JNK signaling pathway. Science 1996. 273 (5276): 792-4. Link

Mohammadi M, Dikic I, Sorokin A, Burgess WH, Jaye M, Schlessinger J. Identification of six novel autophosphorylation sites on fibroblast growth factor receptor 1 and elucidation of their importance in receptor activation and signal transduction. Mol. Cell. Biol. 1996. 16 (3): 977-89. Link

Dikić I. Regulation of HIV-1 infection by chemokine receptors. Acta Med Croatica 1996. 50 (4-5): 163-8. Link

Galisteo ML, Dikic I, Batzer AG, Langdon WY, Schlessinger J. Tyrosine phosphorylation of the c-cbl proto-oncogene protein product and association with epidermal growth factor (EGF) receptor upon EGF stimulation. J. Biol. Chem. 1995. 270 (35): 20242-5. Link

Dikic I, Batzer AG, Blaikie P, Obermeier A, Ullrich A, Schlessinger J, Margolis B. Shc binding to nerve growth factor receptor is mediated by the phosphotyrosine interaction domain. J. Biol. Chem. 1995. 270 (25): 15125-9. Link

Spivak-Kroizman T, Lemmon MA, Dikic I, Ladbury JE, Pinchasi D, Huang J, Jaye M, Crumley G, Schlessinger J, Lax I. Heparin-induced oligomerization of FGF molecules is responsible for FGF receptor dimerization, activation, and cell proliferation. Cell 1994. 79 (6): 1015-24. Link

Dikic I, Schlessinger J, Lax I. PC12 cells overexpressing the insulin receptor undergo insulin-dependent neuronal differentiation. Curr. Biol. 1994. 4 (8): 702-8. Link

Marusić A, Dikić I, Vukicević S, Marusić M. New bone induction by demineralized bone matrix in immunosuppressed rats. Experientia 1992. 48 (8): 783-5. Link