The Structural Genomics Consortium at the Goethe University Frankfurt (SGC Frankfurt) is a research node of the SGC, an international public private partnership and open science network. The SGC catalyses new research areas of human biology by providing high resolution structure information, assay systems and chemical tools. The main focus of the SGC node in Frankfurt are protein kinases, proteins regulating the ubiquitin system as well as epigenetic mechanisms. The site coordinates the Innovative Medicine Initiative (IMI) Program EUbOPEN and it is a partner in the Target2035 initiative, two large international efforts with the goal covering the human proteome with high quality chemical tools.
A promising protein degrader trashed a key oncogenic protein Read more
Feature article in ASBMB Today (2021) Targeting 20,000 proteins by 2035 - by Laurel Oldach Read here
New consortium EUbOPEN will provide tools to unlock disease biology – Congratulation to Stefan Knapp and colleagues from the Goethe University, who just received a prestigious IMI grant for a large-scale effort for the development of an open access chemogenomic compound libraries and chemical probes. The newly formed public-private partnership “Enabling and Unlocking biology in the OPEN” (EUbOPEN) was launched on 1 May 2020, with a total budget of 65.8 million euros covered by a grant from the Innovative Medicines Initiative (IMI) and cash/in-kind contributions from EFPIA companies and IMI Associated Partners and contributions from partners outside of Europe.
Preuss F, Chatterjee D, Mathea S, Shrestha S, St-Germain J, Saha M, Kannan N, Raught B, Rottapel R, Knapp S. Nucleotide Binding, Evolutionary Insights, and Interaction Partners of the Pseudokinase Unc-51-like Kinase 4. Structure, 28, 1184–1196.e6 Read
Berger BT, Amaral M, Kokh DB, Nunes-Alves A, Musil D, Heinrich T, Schröder M, Neil R, Wang J, Navratilova I, Bomke J, Elkins JM, Müller S, Frech M, Wade RC, Knapp S. Structure-kinetic relationship reveals the mechanism of selectivity of FAK inhibitors over PYK2. Cell Chem Biol. 2021 Link
Malik AU, Karapetsas A, Nirujogi RS, Mathea S, Chatterjee D, Pal P, Lis P, Taylor M, Purlyte E, Gourlay R, Dorward M, Weidlich S, Toth R, Polinski NK, Knapp S, Tonelli F, Alessi DR. Deciphering the LRRK code: LRRK1 and LRRK2 phosphorylate distinct Rab proteins and are regulated by diverse mechanisms. Biochem J. 2021 Link
Chief Operating Officer
Tel: +49 (0) 69 798-42501
frankfurt (at) thesgc.org
60438 Frankfurt am Main
The Structural Genomics Consortium is a registered charity (no: 1097737) that receives funds from Bayer AG, Boehringer Ingelheim, Bristol Myers Squibb, Genentech, Genome Canada through Ontario Genomics Institute [OGI-196], EU/EFPIA/OICR/McGill/KTH/Diamond Innovative Medicines Initiative 2 Joint Undertaking [EUbOPEN grant 875510], Janssen, Merck KGaA (aka EMD in Canada and US), Pfizer and Takeda.