The SGC Frankfurt is focused on the development and rational design of selective inhibitors (chemical probes) targeting key signaling molecules and their use for the validation of new targets. Chemical probes are cell-permeable small-molecule modulators of protein function with stringent quality criteria on potency and selectivity. (Read more)
In the framework of the IMI JU2 initiative EUbOPEN, SGC Frankfurt aims to assemble a highly annotated chemogenomics library (CGL). Chemogenomic compounds are pharmacological modulators which interact with products of the genome and alter their biological function (Read more). In contrast to chemical probes which have to fulfil stringent criteria on potency and selectivity, the potency of chemogenomic compounds is often not sufficient to be chemical probes. Thus chemogenomics compounds allow a wider spectrum of targets or target family directed chemogenomic sets.
The research teams focus on the following key research areas: